Barbara Klencke

Barbara Klencke

Company: Sierra Oncology

Job title: Chief Development Officer

Bio:

Dr. Klencke is an accomplished oncology drug developer with a demonstrable track record of success, having made substantial contributions to the development and approval of numerous significant oncology products. Previously, Dr. Klencke served as the Senior Vice President, Development at Onyx Pharmaceuticals, a subsidiary of Amgen Inc., from January 2011 to June 2015, and prior to that was the Group Medical Director in Product Development, Oncology at Genentech, Inc., having joined the company in July 2003. In this period, she led a variety of oncology programs including those for Kyprolis (carfilzomib), Kadcyla (ado-trastuzumab emtansine), Avastin (bevacizumab), and Tarceva (erlotinib). Prior to that, Dr. Klencke served as the Medical Director at Chiron Corporation, a biotechnology company later acquired by Novartis International AG, and as an Assistant Professor of Medicine at the University of California, San Francisco Medical Center. Dr. Klencke holds a BS from Indiana University and an MD from the University of California, Davis.

Seminars:

Live Discussion & Question Time 12:00 pm

What are the clinical cross-learnings for JAK inhibitor application across both blood-related disorders and immune-mediated diseases? How can we refine clinical trial protocols to include clinically meaningful biomarkers with improved predictability of patient response and clinically meaningful endpoints? In what clinical indications do effective combination regimens that include JAK inhibitors play a role and how…Read more

day: Day One

Trials & Progress from MOMENTUM Study in Myelofibrosis 11:20 am

Optimizing clinical trial design with enhanced biological endpoints Demonstrating improvement in anemia and reducing transfusion dependency in patients Exploring perspectives on optimal powering and how that influences developmental milestonesRead more

day: Day One

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