Ruxolitinib and Baricitinib Impair Glycoprotein-VI Mediated Platelet Function
Time: 9:30 am
day: Day Two
- Platelets express all the Janus kinases and several STAT proteins.
- JAK/STAT5 pathways are activated following stimulation of glycoprotein VI with collagen in platelets.
- Ruxolitinib and baricitinib impair platelet granule secretion, adhesion, and aggregation following stimulation with collagen.