Ruxolitinib and Baricitinib Impair Glycoprotein-VI Mediated Platelet Function

Time: 9:30 am
day: Day Two


  • Platelets express all the Janus kinases and several STAT proteins.
  • JAK/STAT5 pathways are activated following stimulation of glycoprotein VI with collagen in platelets.
  • Ruxolitinib and baricitinib impair platelet granule secretion, adhesion, and aggregation following stimulation with collagen.